Effect of protease and helicase mutations on HCV NS3 activity

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Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase.

Hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses multiple enzyme activities. The N-terminal one-third of NS3 primarily functions as a serine protease, while the remaining two-thirds of NS3 serve as a helicase and nucleoside triphosphatase. Whether the multiple enzyme activities of NS3 are functionally interdependent and/or modulated by other viral NS proteins remains unclear. We ...

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ژورنال

عنوان ژورنال: Saudi Journal of Biological Sciences

سال: 2011

ISSN: 1319-562X

DOI: 10.1016/j.sjbs.2010.09.001